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ANT2681

CAT: 0804-HY-176519Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176519Size:1 Each
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Description
ANT2681 is a potent NDM inhibitor with a Ki value of 0.04 μM against NDM-1. ANT2681 also inhibits other MBLs, such as VIM-1 and IMP-1 with Ki values of 0.63 μM and 3.81 μM, respectively. ANT2681 can be used in combination with Meropenem to inhibit infections caused by NDM-producing Enterobacteriaceae[1].
CAS Number
2270184-16-0
UNSPSC
12352211
Target
Bacterial; Beta-lactamase
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C(C1=C(NS(=O)(C2=CC(F)=C(C(F)=C2)NC(NNC(N)=N)=O)=O)SC=N1)O
Molecular Formula
C12H11F2N7O5S2
Molecular Weight
435.39
References & Citations
[1]Davies DT, et al. ANT2681: SAR Studies Leading to the Identification of a Metallo-β-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae. ACS Infect Dis. 2020 Sep 11;6 (9) :2419-2430.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T211170-01ANT2681

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