Palbociclib-C4-Boc

• Description :

  Palbociclib-C4-Boc is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for CDK4/6 Palbociclib (HY-50767) and a PROTAC linker (HY-W007803), which recruits E3 ligases. Palbociclib-C4-Boc can be used for synthesis of PROTAC BSJ-03-204 (HY-136250) [1].

• CAS Number :

  [2139329-48-7]

• UNSPSC :

  12352005

• Target :

  CDK; Target Protein Ligand-Linker Conjugates

• Related Pathways :

  Cell Cycle/DNA Damage; PROTAC

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Smiles :

  O=C1N(C2CCCC2)C3=NC(NC4=CC=C(N(CC5)CCN5CCCCNC(OC(C)(C)C)=O)C=N4)=NC=C3C(C)=C1C(C)=O

• Molecular Formula :

  C33H46N8O4

• Molecular Weight :

  618.77

• References & Citations :

  [1]Jiang B, et al. Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58 (19) :6321-6326.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CDK4; CDK6