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Palbociclib-C4-Boc

CAT: 0804-HY-176365Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176365Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Palbociclib-C4-Boc is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for CDK4/6 Palbociclib and a PROTAC linker (HY-W007803), which recruits E3 ligases. Palbociclib-C4-Boc can be used for synthesis of PROTAC BSJ-03-204 (HY-136250).
CAS Number
2139329-48-7
UNSPSC
12352005
Target
CDK; Target Protein Ligand-Linker Conjugates
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1N(C2CCCC2)C3=NC(NC4=CC=C(N(CC5)CCN5CCCCNC(OC(C)(C)C)=O)C=N4)=NC=C3C(C)=C1C(C)=O
Molecular Formula
C33H46N8O4
Molecular Weight
618.77
References & Citations
[1]Jiang B, et al. Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58 (19) :6321-6326.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4; CDK6

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