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OXPHOS-IN-2

CAT: 0804-HY-176284Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176284Size:1 Each
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Description
OXPHOS-IN-2 is an orally active OXPHOS inhibitor. OXPHOS-IN-2 exhibits potent inhibitory activity in PC9 (IC50 = 12.3 nM) and Bxpc-3 cells (IC50 = 250 nM in glucose medium, IC50 = 17.5 nM in galactose medium) . OXPHOS-IN-2 decreases the NADH/NAD+ ratio and reduces ATP levels. OXPHOS-IN-2 induces tumor cells apoptosis by activating reactive oxygen species (ROS) and downregulating the level of Nrf2. OXPHOS-IN-2 can be used for research on cancer such as non-small cell lung cancer and pancreatic cancer[1].
UNSPSC
12352005
Target
AMPK; Apoptosis; Keap1-Nrf2; Mitochondrial Metabolism; Oxidative Phosphorylation; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC=CC(N5CCC(S(=O)(C)=O)CC5)=C4)C(C6CC6)=N3)=N2)C=C1
Molecular Formula
C27H27F3N6O4S
Molecular Weight
588.60
References & Citations
[1] Cao L, et al. Synthesis and evaluation of new 5- (1H-1,2,4-triazol-3-yl) -1,2,4-oxadiazole derivatives and their application as OXPHOS inhibitors. Eur J Med Chem. 2025 Jun 25;297:117903.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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