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IXA62

CAT: 0804-HY-176040-04Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-176040-04Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IXA62 is an orally active and selective IRE1/XBP1s activator (EC50 = 0.31 μM) that reduces Aβ secretion. IXA62 enhances glucose-stimulated insulin secretion from rat insulinoma cells[1].
CAS Number
956783-34-9
UNSPSC
12352005
Target
Amyloid-β; IRE1
Related Pathways
Cell Cycle/DNA Damage; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Metabolic Disease; Neurological Disease
Purity
99.88
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
CN1C2=CC=CC=C2C(C(CN3C(NC(C4CC4)(C3=O)C)=O)=O)=C1C5=CC=CC=C5
Molecular Formula
C24H23N3O3
Molecular Weight
401.46
References & Citations
[1]Jie Sun, et al. Identification of a Selective Pharmacologic IRE1/XBP1s Activator with Enhanced Tissue Exposure. ACS Chem Biol. 2025 Apr 15.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

5-cyclopropyl-5-methyl-3-[2-(1-methyl-2-phenyl-1H-indol-3-yl)-2-oxoethyl]imidazolidine-2,4-dione
CAS Number956783-34-9
PubChem CID4781365
IUPAC Name5-cyclopropyl-5-methyl-3-[2-(1-methyl-2-phenylindol-3-yl)-2-oxoethyl]imidazolidine-2,4-dione
Molecular FormulaC24H23N3O3
Molecular Weight401.5
XLogP3.3
Topological Polar Surface Area71.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Heavy Atom Count30
Formal Charge0
Complexity729
SMILES
CC1(C(=O)N(C(=O)N1)CC(=O)C2=C(N(C3=CC=CC=C32)C)C4=CC=CC=C4)C5CC5
InChI
InChI=1S/C24H23N3O3/c1-24(16-12-13-16)22(29)27(23(30)25-24)14-19(28)20-17-10-6-7-11-18(17)26(2)21(20)15-8-4-3-5-9-15/h3-11,16H,12-14H2,1-2H3,(H,25,30)
InChIKey
TUVMLZMPSJOPGY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-cyclopropyl-5-methyl-3-[2-(1-methyl-2-phenyl-1H-indol-3-yl)-2-oxoethyl]imidazolidine-2,4-dione
CAS: 956783-34-9
CID: 4781365
Formula: C24H23N3O3
MW: 401.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight401.5
XLogP33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass401.17394160
Monoisotopic Mass401.17394160
Topological Polar Surface Area71.4 Ų
Heavy Atom Count30
Formal Charge0
Complexity729
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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