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(E) -Belizatinib

CAT: 0804-HY-17603ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-17603ASize:1 Each
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Description
(E) -Belizatinib ((E) -TSR-011) ) (compound 36), the (E) -isomer of Belizatinib , is a potent, selective and orally active anaplastic lymphoma kinase (ALK) Inhibitor with an enzymatic IC50 of 0.005 μM and a cellular IC50 of 0.048 μM. (E) -Belizatinib shows >61-fold selectivity over JAK2, SRC, and IGF1R. (E) -Belizatinib shows favorable potency and PK characteristics in rats and dogs. (E) -Belizatinib can be used for ALK-driven cancer research[1].
CAS Number
1388225-72-6
Product Name Alternative
(E) -TSR-011
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK)
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(C1=CC=C(C=C1)F)NC(N([C@H]2CC[C@H](CC2)C(NC(C)C)=O)C3=C4)=NC3=CC=C4CN5CCC(CC5)C(C)(O)C
Molecular Formula
C33H44FN5O3
Molecular Weight
577.73
References & Citations
[1]Lewis RT, et al. The discovery and optimization of a novel class of potent, selective, and orally bioavailable anaplastic lymphoma kinase (ALK) inhibitors with potential utility for the treatment of cancer. J Med Chem. 2012 Jul 26;55 (14) :6523-40.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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