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SARM1-IN-7

CAT: 0804-HY-175879Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175879Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SARM1-IN-7 is a potent active site (orthosteric) and orally active SARM1 inhibitor. SARM1-IN-7 continuously activates the enzymatic activity of SARM1, thereby exacerbating the depletion of NAD at sub-minimal concentrations. SARM1-IN-7 demonstrated dual benefits in the SARM1-activated cell models and mouse models: a high dose exerted a cell/neuron protective effect, while a low dose exacerbated cell/neuron damage. SARM1-IN-7 can be used for the study of axon degeneration[1].
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Related Pathways
Immunology/Inflammation
Field of Research
Neurological Disease
Smiles
C[C@H](N(C)C(NC(F)(F)F)=O)C1=CC=NC=C1
Molecular Formula
C10H12F3N3O
Molecular Weight
247.22
References & Citations
[1]Leahey, R.R, et al. Therapeutic safety implications of SARM1 active site inhibitors: subinhibitory concentrations cause neurodegeneration. npj Drug Discov. 2, 21 (2025) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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