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ADAM17-IN-1

CAT: 0804-HY-175876Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175876Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ADAM17-IN-1 is a selective inhibitor of ADAM17. ADAM17-IN-1 inhibits ADAM17 activity to reduce metabolic activity of dendritic cells (DCs), impair DC antigen-presenting function, suppress allergen-specific Th2 cell polarization, and reduce Th2 cytokine (IL-4, IL-5, IL-13) secretion. ADAM17-IN-1 demonstrates protective efficacy against house dust mite (HDM) -induced type 2/eosinophilic airway inflammation in mice. ADAM17-IN-1 can be used for the study of type 2-high allergic asthma[1].
CAS Number
1802395-34-1
UNSPSC
12352005
Target
Interleukin Related; MMP
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
CCC[C@@H](CNC(C1=O)=O)N1C[C@H](CCC2)N2C[C@H](N3C[C@@H](N(C(C3=O)=O)CCC4=CC=CC=C4)CC5=CC=CC=C5)CC6CCCCC6
Molecular Formula
C40H55N5O4
Molecular Weight
669.90
References & Citations
[1]Jaiswal AK, et al. Targeting ADAM17 to dampen dendritic cell-mediated type 2 immune responses and airway inflammation associated with allergic asthma. Sci Rep. 2025 Aug 25;15 (1) :31253.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ADAM17

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