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ADAM17-IN-1

CAT: 0013-GTR19273123-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273123-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ADAM17-IN-1 is a selective ADAM17 inhibitor. It functions by reducing dendritic cell (DC) metabolic activity through ADAM17 inhibition, thereby impairing DC antigen presentation, suppressing allergen-specific Th2 cell polarization, and decreasing the secretion of Th2 cytokines (IL-4, IL-5, IL-13) . In mouse models of house dust mite (HDM) -induced type 2/eosinophilic airway inflammation, ADAM17-IN-1 demonstrates protective effects. This compound can be utilized in research on type 2 hyperreactive allergic asthma.
CAS Number
1802395-34-1
Smiles
[C@H] (CN1[C@H] (CN2[C@@H] (CCC) CNC (=O) C2=O) CCC1) (CC3CCCCC3) N4C[C@H] (CC5=CC=CC=C5) N (CCC6=CC=CC=C6) C (=O) C4=O
Molecular Formula
C40H55N5O4
Molecular Weight
669.91
Storage Conditions
-20°C
Notes
For research use only.

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