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USP30-IN-20

CAT: 0804-HY-175826Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175826Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
USP30-IN-20 is an orally active USP30 inhibitor (Kd = 1.61 μM, IC50 = 12.8 μM) . USP30-IN-20 induces ferroptosis by promoting ubiquitination-mediated degradation of GPX4. USP30-IN-20 inhibits the proliferation, migration, invasion, and stemness of prostate cancer cells. USP30-IN-20 induces G0/G1 cell cycle arrest and ROS levels in prostate cancer cells. USP30-IN-20 exhibits significant anti-tumor efficacy in PC3 cell subcutaneous xenografts in mice. USP30-IN-20 can be used for the study of advanced prostate cancer[1].
UNSPSC
12352005
Target
Deubiquitinase; Ferroptosis; Glutathione Peroxidase; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
ClC(C=CC=C1)=C1[Se]C2=C(C)C3=C(O2)CC(C)CC3=O
Molecular Formula
C16H15ClO2Se
Molecular Weight
353.70
References & Citations
[1]Xu L, et al. Discovery of a selenium-containing compound as a promising ferroptosis inducer attenuates prostate cancer progression. Eur J Med Chem. 2025 Dec 5;299:118067.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4; USP30

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