Products for Research Use Only
RegisterLogin

MM927

CAT: 0804-HY-175783-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-175783-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MM927 is a potent NVL inhibitor, with an IC50 of 0.053 μM. MM927 blocks 60S ribosomal subunit biogenesis in the nucleolus. MM927 induces half-mer polysomes, cell cycle arrest at G1/S and G2/M and apoptosis in cells. MM927 demonstrates antitumor efficacy in MOLM-13 AML and HCT116 CRC xenograft models. MM927 can be used for the study of cancers such as acute myeloid leukemia (AML) and colorectal cancer (CRC) [1].
CAS Number
3065567-21-4
UNSPSC
12352005
Target
Apoptosis
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C1OC2=CC=C(C(NC3=CC=C4C(SC5=CC(F)=CC=C5C(N4CC#CC)=O)=C3)=O)C=C2N1C
Molecular Formula
C26H18FN3O4S
Molecular Weight
487.50
References & Citations
[1]Guo HH, et al. A small molecule inhibitor of NVL suppresses tumor growth by blocking ribosome biogenesis. bioRxiv [Preprint]. 2025 Aug 1:2025.07.31.667081.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
GTR19273058-01MM927

Popular Products