EN1033

CAT: 0804-HY-175759-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-175759-01Size:5 mg

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Description

EN1033 is a covalent immune regulatory transcription factor 5/8 (IRF5/8) molecular glue degrader. EN1033 degrades IRF5 in a proteasome-dependent manner. EN1033 engages and degrades IRF8 more robustly and rapidly. EN1033 covalently targets C28 and C223 to destabilize and degrade IRF5 and IRF8 respectively, thereby inhibiting their pro-inflammatory transcriptional activity. EN1033 serves as a promising tool for the study of autoimmune and inflammatory disorders[1].

CAS Number

2193367-28-9

UNSPSC

12352005

Target

IFNAR; Molecular Glues

Related Pathways

Immunology/Inflammation; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Purity

99.96

Smiles

C=CC(N1C2=CC=CC=C2CN3C(CCC3)C1)=O

Molecular Formula

C15H18N2O

Molecular Weight

242.32

References & Citations

[1]Do TC, et al. Covalent Degraders of Immune Regulatory Transcription Factors IRF8 and IRF5. bioRxiv [Preprint]. 2025 Aug 3:2025.08.03.668300.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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