PS-341 (MG-341)

CAT: 0421-27715-2Size: 5 mgDry Ice: NoHazardous: No
CAT#:0421-27715-2Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PS-341 (Pyz-Phe-boroLeu) is the active ingredient in Bortezomib. PS-341 is a reversible, cell permeable, potent, and selective proteasome inhibitor (Ki=0.6 nM) . It binds the catalytic site of the 26S proteasome with high affinity and specificity. Inhibits proliferation of a number of tumor cell lines (IC50=7 nM) . Inhibits TNF synthesis and FGF-induced angiogenesis.
CAS Number
179324-69-7
Applications
Useful for as a potent, cell permeable proteasome inhibitor for drug discovery research.
Purity
> 98% by HPLC.
Format
White powder
Solubility
Soluble in DMSO
Molecular Formula
C19H25BN4O4
Shipping Conditions
Room Temperature
Storage Conditions
Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 week.
Calculated Molecular Weight
384.2 Da

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