Products for Research Use Only
RegisterLogin

SCL-1

CAT: 0804-HY-175604-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-175604-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
SCL-1 is an orally active anti-PD-1/PD-L1 inhibitor. SCL-1 can inhibit PD-1/PD-L1 binding. SCL-1 increases T cells, B cells and natural killer cells. SCL-1 exerts strong tumor growth inhibitory effects that were mediated by effector T-cell induction inside tumors and the up-regulated expression of long non-coding RNAs as neoantigens leading to cytotoxic T lymphocyte activation. SCL-1 can be used for the research of cancer, such as triple-negative breast cancer[1][2].
CAS Number
1061105-16-5
UNSPSC
12352100
Target
PD-1/PD-L1
Related Pathways
Immunology/Inflammation
Field of Research
Cancer
Smiles
CC1CCCCN1C(C2CCN(CC2)C3=NN4C(C=C3)=NN=C4C(F)(F)F)=O
Molecular Formula
C18H23F3N6O
Molecular Weight
396.41
References & Citations
[1]Ikeya T, et al. Impact of the PD-1/PD-L1 inhibitor SCL-1 on MDA-MB231 tumor growth in a humanized MHC-double knockout NOG mouse model. Sci Rep. 2025 Jul 24;15 (1) :26918.|[2]Akiyama Y, et al. Development of Novel Small Antitumor Compounds Inhibiting PD-1/PD-L1 Binding. Anticancer Res. 2022 Nov;42 (11) :5233-5247.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-N6838-011,1,1,1-Kestohexaose
HY-157129AMPK-α1β1γ1 activator 1
HY-1336231,1,1-Tribromoacetone
HY-149536TWIK-1/TREK-1-IN-1
HY-W160628S1,1,1-Trimethoxypropane-d5
HY-133630-011-Bromo-1,1-dichloroacetone
HY-W881439-011- (1,1-Dimethylethyl) tridecanedioate
HY-W032015S11-Bromooctane-1,1-d2
HY-1336291,1,1,3-Tetrachloroacetone
HY-112773-011,1′,1′′,1′′′-[1,4-Piperazinediylbis (2,1-ethanediylnitrilo) ]tetrakis[2-dodecanol]

Alternative Products

CatalogName
ARC0806SCL-1
MBS634416-01Scl-70
GWB-E72C88Scl-70 Antigen
GWB-D82F78Scl-70 Antibody
E22-HC9088Scl-70 ELISA
513979SCLY (SCL) discontinued
208541Scl-70, Control
290053-01Tetrahydroxyazon SCl discontinued
REC31994-500Dengue Virus Serotype 1 VLP (SCL)
YP-W14908-01Human Scl-70 IgG antibody (Scl-70 IgG) ELISA Kit

Popular Products