SRI-45949

CAT: 0804-HY-175534Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175534Size:1 Each
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Description
SRI-45949 is an allosteric modulator of the HIV-DAT-Tat interaction. SRI-45949 has IC50 values of 9.56 μM and 9.34 μM for [3H]DA uptake and [3H]WIN35,428 binding, respectively. SRI-45949 can be used in research related to HIV-associated neurocognitive disorders[1].
UNSPSC
12352005
Target
Dopamine Receptor; HIV
Related Pathways
Anti-infection; GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-anti-virus
Field of Research
Infection; Neurological Disease
Smiles
CCC(CNC1=NC(C(C(C)=C2)=CN3C2=NC=C3)=NC4C1CCCC4)C5=CC=CC=C5
Molecular Formula
C26H31N5
Molecular Weight
413.56
References & Citations
[1]Nguyen TH, et al. Synthesis and evaluation of novel substituted N- (2-phenylbutyl) -5,6,7,8-tetrahydro-quinazolin-4-amines as allosteric modulators of HIV-DAT-tat interaction. Bioorg Med Chem Lett. 2025 Dec 1;128:130345.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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