6PGD-IN-2

• Description:

  6PGD-IN-2 is an uncompetitive 6-phosphogluconate dehydrogenase (6PGD) inhibitor with an IC50 of 5.1 μM. 6PGD-IN-2 disrupts 6PGD oligomerization in a substrate-dependent manner. 6PGD-IN-2 results in a decrease of NADPH and Ru-5-P production as well as DNA synthesis in A549 cells. 6PGD-IN-2 can used for the studies of non-small cell carcinoma and liver cancer[1].

• UNSPSC:

  12352005

• Target:

  DNA/RNA Synthesis

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Smiles:

  O=C(NC1=NN=C(C2=CC=C(Br)C=C2F)S1)CC3=CC=C(Cl)C(Cl)=C3

• Molecular Formula:

  C16H9BrCl2FN3OS

• Molecular Weight:

  461.14

• References & Citations:

  [1]Zhang R, et al. Discovery of N- (1,3,4-Thiadiazol-2-yl) amide Derivatives as Uncompetitive Inhibitors of 6-Phosphogluconate Dehydrogenase. J Med Chem. 2025 Aug 14;68 (15) :15403-15421.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported