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UNC7437

CAT: 0804-HY-175476Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175476Size:1 Each
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Description
UNC7437 is a inositol phosphate multikinase (IPMK) inhibitor, with an IC50 value of 26.2 nM. UNC7437 exhibits anti-proliferative activity against glioblastoma cells. UNC7437 decreases the accumulation of InsP4, InsP5, and InsP6 in cells. UNC7437 can be used for the study of TEN-negative glioblastoma models[1].
CAS Number
2967647-41-0
UNSPSC
12352005
Target
IPK Superfamily
Related Pathways
Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(O)/C=C/C1=CC2=C(C3=CC(C)=CC(C)=C3)ON=C2C=C1
Molecular Formula
C18H15NO3
Molecular Weight
293.32
References & Citations
[1]Zhou Y, et al. Design, Synthesis, and Cellular Characterization of a New Class of IPMK Kinase Inhibitors. J Med Chem. 2025 Aug 14;68 (15) :15446-15460.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

(E)-3-[3-(3,5-dimethylphenyl)-2,1-benzoxazol-5-yl]prop-2-enoic acid
CAS Number2967647-41-0
PubChem CID169143908
IUPAC Name(E)-3-[3-(3,5-dimethylphenyl)-2,1-benzoxazol-5-yl]prop-2-enoic acid
Molecular FormulaC18H15NO3
Molecular Weight293.3
XLogP4
Topological Polar Surface Area63.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count22
Formal Charge0
Complexity426
SMILES
CC1=CC(=CC(=C1)C2=C3C=C(C=CC3=NO2)/C=C/C(=O)O)C
InChI
InChI=1S/C18H15NO3/c1-11-7-12(2)9-14(8-11)18-15-10-13(4-6-17(20)21)3-5-16(15)19-22-18/h3-10H,1-2H3,(H,20,21)/b6-4+
InChIKey
GVBOPZONHGVWNG-GQCTYLIASA-N
Chemical Structure
2D Structure
2D structure of (E)-3-[3-(3,5-dimethylphenyl)-2,1-benzoxazol-5-yl]prop-2-enoic acid
CAS: 2967647-41-0
CID: 169143908
Formula: C18H15NO3
MW: 293.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight293.3
XLogP34
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass293.10519334
Monoisotopic Mass293.10519334
Topological Polar Surface Area63.3 Ų
Heavy Atom Count22
Formal Charge0
Complexity426
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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