K-757

• Description :

  K-757 is a GPR40 agonist with an EC50 of 2.1 ± 0.2 nM for human GPR40. K-757 exhibits a half-life of 1-11 h in Preclinical Species. K-757 stimulates GLP-1 secretion and has potential applications in bariatric research[1].

• UNSPSC :

  12352005

• Target :

  GLP Receptor

• Related Pathways :

  GPCR/G Protein

• Field of Research :

  Metabolic Disease

• Smiles :

  O=P(CC[C@@H](C1CC1)C2=CC=CC(OCC3CCN(C4=CC(OC)=CC=C4CCCC(C)(C)C)CC3)=C2)O

• Molecular Formula :

  C32H48NO4P

• Molecular Weight :

  541.70

• References & Citations :

  [1]Moyes CR, et al. Discovery of Gut-Targeted GPR40 Agonist K-757 and GPR119 Agonist K-833, a Combination Treatment for Metabolic Disorders.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported