GlcNAc-MurNAc

• Description:

  GlcNAc-MurNAc, a disaccharide, is a TLR4 agonist with a Kd of 383 μM for murine TLR4. GlcNAc-MurNAc directly binds to TLR4 and activates its downstream NF-κB and IRF pathways. GlcNAc-MurNAc improves Dextran sulfate sodium salt (DSS) (HY-116282C) -induced colitis in mice through a TLR4-dependent mechanism. GlcNAc-MurNAc can be used for the study of inflammatory bowel disease[1].

• UNSPSC:

  12352005

• Target:

  Caspase; Interleukin Related; NF-κB; TNF Receptor; Toll-like Receptor (TLR)

• Related Pathways:

  Apoptosis; Immunology/Inflammation; NF-κB

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Inflammation/Immunology

• Smiles:

  OC([C@@H](C)O[C@H]([C@H](C(O[C@@H]1CO)O)NC(C)=O)[C@@H]1O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)NC(C)=O)=O

• Molecular Formula:

  C19H32N2O13

• Molecular Weight:

  496.46

• References & Citations:

  [1]Li C, et al. Gut microbiota-derived GlcNAc-MurNAc is a TLR4 agonist that protects the host gut. Nat Commun. 2025 Jul 1;16 (1) :5577.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  IL-1; IL-12; IL-6; NF-κB; TLR4

• CAS Number:

  41137-10-4