GlcNAc-MurNAc

CAT: 0931-MF-0118611-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0118611-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
4500-70-3
Target
Interleukin|||TLR|||NF-?B|||Caspase|||TNF
Related Pathways
NF-?B|||Proteases/Proteasome|||Immunology/Inflammation|||Apoptosis
Bioactivity
GlcNAc-MurNAc is a disaccharide and mild TLR4 agonist with a Kd of 383 ?M for mouse TLR4. It directly binds to TLR4, activating the downstream NF-?B and IRF pathways. Additionally, GlcNAc-MurNAc ameliorates dextran sulfate sodium salt (DSS) -induced colitis in mice through a TLR4-dependent mechanism, making it useful for inflammatory bowel disease research.
Smiles
O([C@H]1[C@H](O[C@@H](C(O)=O)C)[C@@H](NC(C)=O)[C@H](O)O[C@@H]1CO)[C@H]2[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O2
Molecular Formula
C19H32N2O13
Molecular Weight
496.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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