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MST3-IN-1

CAT: 0804-HY-175208Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175208Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MST3-IN-1 is a selective and orally active MST3 inhibitor, with an IC50 of 122.4 nM. MST3-IN-1 shows antiproliferative activity against HepG2 cell. MST3-IN-1 effectively induces apoptosis in HepG2 cells, and halts the cell cycle at the G2/M transition. MST3-IN-1 significantly suppressed tumor growth in HepG2 xenograft mice. MST3-IN-1 can be used for the study of liver cancer[1].
CAS Number
3095435-97-2
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; Hippo (MST)
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(C1=CN(C2CC2)C3=CC(N4CCNCC4)=C(C=C3C1=O)F)NC5=NC6=C(S5)C=C(OC(F)(F)F)C=C6
Molecular Formula
C25H21F4N5O3S
Molecular Weight
547.52
References & Citations
[1]Li D, et al. Design and synthesis of Riluzole-Ciprofloxacin hybrids as selective MST3 inhibitors for cancer treatment. Eur J Med Chem. 2025 Jun 28;297:117923.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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