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Pro-FTY

CAT: 0804-HY-175201Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175201Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pro-FTY, a FTY720 anticancer prodrug, is a sphingosine-1-phosphate (S1P) (HY-108496) inhibitor. pro-FTY specifically inhibits S1P signaling in cancer cells using a drug delivery system (DDS) that reacts with acrolein. pro-FTY significantly inhibits the survival of breast cancer cells, including multidrug-resistant cells and its organoids resistant to Paclitaxel (HY-B0015) or Doxorubicin (HY-15142A). pro-FTY potently suppresses tumor growth in 4T1 cells or organoids xenograft tumors mice model while avoiding lymphocytopenia[1].
CAS Number
3064707-13-4
UNSPSC
12352005
Target
LPL Receptor; STAT
Related Pathways
GPCR/G Protein; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
OCC(NC(OCC1=CC(C(C)C)=C(N=[N+]=[N-])C(C(C)C)=C1)=O)(CO)CCC2=CC=C(CCCCCCCC)C=C2
Molecular Formula
C33H50N4O4
Molecular Weight
566.77
References & Citations
[1]Nagahashi M, et al An Acrolein-Based Drug Delivery System Enables Tumor-Specific Sphingosine-1-Phosphate Targeting in Breast Cancer without Lymphocytopenia. Cancer Res Commun. 2025 Jun 1;5 (6) :981-993.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3

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