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MP1202

CAT: 0804-HY-175197Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175197Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MP1202 is a dual-functional agonist of MOR and KOR with EC50s of 0.32 and 0.13 μM for mMOR-1 and mKOR-1, respectively. MP1202 has functional selectivity with reduction of β-arrestin1/2 recruitment but significant activation of G-protein and Gα-subtype at hMOR and hKOR. MP1202 has potent antinociceptive effects without typical opioid side effects, but it shows conditioned place preference and aversion behaviors in subtype-selective opioid KO mice model, promising for analgesia research[1].
CAS Number
2578974-82-8
UNSPSC
12352005
Target
Arrestin; Opioid Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C1=CC(I)=CC=C1)N[C@H]2[C@@](O3)([H])[C@]4(CCN5CC6CC6)C(C3=C7O)=C(C=C7)C[C@]5([H])[C@]4([H])CC2
Molecular Formula
C27H29IN2O3
Molecular Weight
556.44
References & Citations
[1]Varga BR, et al. Synthesis and Pharmacology of a Morphinan-Derived Dual Mu-Kappa Opioid Receptor Agonist Analgesic. ACS Chem Neurosci. 2025 Jul 16;16 (14) :2714-2737.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Arrestin-2/β-Arrestin 1; κ Opioid Receptor/KOR; μ Opioid Receptor/MOR

Alternative Products

CatalogName
GTR19264018-01MP1202

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