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MP1202

CAT: 0931-T211669-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211669-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2578974-82-8
Target
Opioid Receptor, Arrestin
Related Pathways
Endocrinology/Hormones, GPCR/G Protein, Neuroscience
Bioactivity
MP1202 is a dual agonist for MOR and KOR, with EC50 values of 0.32 μM for mMOR-1 and 0.13 μM for mKOR-1. It exhibits functional selectivity by reducing β-arrestin1/2 recruitment in hMOR and hKOR while significantly activating G protein and Gα subtypes. In opioid receptor subtype knockout mouse models, MP1202 demonstrates potent antinociceptive effects without typical opioid side effects, albeit it induces conditioned place preference and aversion behaviors, indicating potential for analgesic research.
Smiles
N(C(=O)C1=CC(I)=CC=C1)[C@H]2[C@]3([C@]45C=6C(O3)=C(O)C=CC6C[C@]([C@@]4(CC2)[H])(N(CC7CC7)CC5)[H])[H]
Molecular Formula
C27H29IN2O3
Molecular Weight
556.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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