Chloroguanabenz (acetate)

• Description:

  Chloroguanabenz (acetate) is an antiprion agent and a derivative of the α2-adrenergic receptor agonist guanabenz. Chloroguanabenz (acetate) can inhibit the formation of prion in yeast and mammalian in vitro assays. Chloroguanabenz (acetate) can reduce the levels of truncated Huntingtin derivative Htt48 in HEK293T cells. Chloroguanabenz (acetate) can be studied in research on Huntington’s disease[1][2].

• Product Name Alternative:

  GAh (acetate)

• UNSPSC:

  12352101

• Target:

  Adrenergic Receptor

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Field of Research:

  Infection; Neurological Disease

• Smiles:

  ClC1=C(C(Cl)=CC=C1Cl)/C=N/NC(N)=N.OC(C)=O

• Molecular Formula:

  C10H11Cl3N4O2

• Molecular Weight:

  325.58

• References & Citations:

  [1]Anne Bertolotti and Marc Blondel, Use of chlorine guanabenz derivatives for treating polyglutamine expansion associated diseases. US7932422B2.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2242615-97-8]