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MRC-G-001

CAT: 0804-HY-175009Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175009Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MRC-G-001 is a Genipin derivative with an IC50 of 117 μM against A549 cancer cells. MRC-G-001 inhibits the phosphorylation of EGFR, JAK1, and STAT3, and modulates epithelial-mesenchymal transition (EMT) -related protein expression, thereby attenuating cell migration and invasion. MRC-G-001 induces cell cycle arrest and cell apoptosis. MRC-G-001 can be used for the study of cancers such as non-small-cell lung cancer[1].
UNSPSC
12352005
Target
Apoptosis; EGFR; JAK; STAT
Related Pathways
Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
[H][C@]12CC=C([C@]1([C@@H](OC=C2C(OC)=O)OC(C)C)[H])CNCC3=CC=CC=C3
Molecular Formula
C21H27NO4
Molecular Weight
357.44
References & Citations
[1]Kim DH, et al. Genipin derivative induced the apoptosis and inhibited the invasion and migration of A549 cancer cells via regulation of EGFR/JAK1/STAT3 signaling. Bioorg Med Chem Lett. 2025 Jun 29;128:130320.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK1; STAT3

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