LC-MF-4

CAT: 0804-HY-174981Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-174981Size:1 Each
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Description
LC-MF-4 is a selective FGFR3 PROTAC degrader with a DC50 of 30.89 nM in KMS-11 cells. LC-MF-4 inhibits the metabolic function of FGFR3-TACC3 fusion positive cancers with reduction of ATP synthesis and inhibition of mitochondrial biogenesis genes. LC-MF-4 has potent antitumor activity in the Ba/F3-FGFR3-TACC3 xenograft mice model. LC-MF-4 can be used for FGFR3-altered cancers like bladder cancer and urothelial carcinoma (UC) research[1]. Pink: FGFR3 ligand (HY-175414) ; Blue: VHL ligase ligand (HY-125905) ; Black: linker (HY-Y1224)
UNSPSC
12352005
Target
ATP Synthase; FGFR; PROTACs
Related Pathways
Membrane Transporter/Ion Channel; PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
COC1=CC(OC)=C(C(NC(N(C2=NC=NC(CC3=CC=C(C=C3)N4CCN(CC4)CCCCCOC5=CC(C6=C(N=CS6)C)=CC=C5CNC([C@@H]7C[C@H](CN7C([C@H](C(C)(C)C)NC(C8(CC8)F)=O)=O)O)=O)=C2)C)=O)=C1Cl)Cl
Molecular Formula
C56H69Cl2FN10O8S
Molecular Weight
1132.18
References & Citations
[1]Zheng L, et al. LC-MF-4, a Novel FGFR3 Degrader for Therapeutic Intervention in FGFR3-Altered Cancers. J Med Chem. 2025 Jul 10;68 (13) :13858-13871.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FGFR3

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