Products for Research Use Only
RegisterLogin

Dac590

CAT: 0804-HY-174979-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-174979-02Size:10 mM - 1 mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Dac590 is an orally active FTO inhibitor. Dac590 has a robust antiproliferative effect on AML cells, and induces apoptosis and cell cycle G1 arrest by inhibiting oncogenic FTO signaling. Dac590 significantly inhibits tumor growth and prolongs survival with no observed toxicity in acute myeloid leukemia (AML) xenograft mcie model, and shows a synergistic effect combined with Decitabine.
CAS Number
3084407-00-8
UNSPSC
12352005
Target
Apoptosis; Fat Mass and Obesity-associated Protein (FTO)
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Purity
96.15
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC(C1=CC(OC)=CC=C1NC2=C(C=C(C=C2Cl)C3=C(ON=C3C)C)F)=O
Molecular Formula
C19H16ClFN2O4
Molecular Weight
390.79
References & Citations
[1]Yang T, et al. Development of Orally Bioavailable FTO Inhibitors with Potent Antileukemia Efficacy. J Med Chem. 2025 Jul 10;68 (13) :13714-13727.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

2-[2-Chloro-4-(3,5-dimethyl-1,2-oxazol-4-yl)-6-fluoroanilino]-5-methoxybenzoic acid
CAS Number3084407-00-8
PubChem CID176489950
IUPAC Name2-[2-chloro-4-(3,5-dimethyl-1,2-oxazol-4-yl)-6-fluoroanilino]-5-methoxybenzoic acid
Molecular FormulaC19H16ClFN2O4
Molecular Weight390.8
XLogP5.1
Topological Polar Surface Area84.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count27
Formal Charge0
Complexity528
SMILES
CC1=C(C(=NO1)C)C2=CC(=C(C(=C2)Cl)NC3=C(C=C(C=C3)OC)C(=O)O)F
InChI
InChI=1S/C19H16ClFN2O4/c1-9-17(10(2)27-23-9)11-6-14(20)18(15(21)7-11)22-16-5-4-12(26-3)8-13(16)19(24)25/h4-8,22H,1-3H3,(H,24,25)
InChIKey
LPUCIEIAOLPFAI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-[2-Chloro-4-(3,5-dimethyl-1,2-oxazol-4-yl)-6-fluoroanilino]-5-methoxybenzoic acid
CAS: 3084407-00-8
CID: 176489950
Formula: C19H16ClFN2O4
MW: 390.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight390.8
XLogP35.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass390.0782629
Monoisotopic Mass390.0782629
Topological Polar Surface Area84.6 Ų
Heavy Atom Count27
Formal Charge0
Complexity528
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19260135-01Dac590

Popular Products