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SK60

CAT: 0804-HY-174978Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174978Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SK60 is a dimethylated derivative of GSK321 with low nanomolar potency and high selectivity for IDH1R132H (IC50 = 14.5 nM). SK60 can be used as a tracer for brain imaging with the fluorescent label [18F][1].
UNSPSC
12352005
Target
Isocitrate Dehydrogenase (IDH)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Smiles
CC1=CC=CC(NC(C2=NN(C3=C2CN(CC3(C)C)C(C4=CC=CN4)=O)CC5=CC=C(C=C5)F)=O)=C1
Molecular Formula
C28H28FN5O2
Molecular Weight
485.55
References & Citations
[1]Sarandeep Kau, et al., From Inhibitors to PET: SAR-Based Development of [18F]SK60 for mIDH1 Imaging. J. Med. Chem. 2025, 68, 13, 13750–13771.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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