GJ19

CAT: 0804-HY-174830-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-174830-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

GJ19 is a PD-L1 inhibitor with an IC50 of 32.06 nM. GJ19 can effectively bind to human/murine PD-L1 protein with KD values of 171 and 290 nM, respectively. GJ19 concentration-dependently promotes HepG2 cell mortality in a co-culture model of HepG2/hPD-L1 and Jurkat T/hPD-1 cells. GJ19 effectively suppresses tumor growth in a B16-F10 melanoma mouse model. GJ19 can be used for the study of tumor immunotherapy[1].

UNSPSC

12352100

Target

PD-1/PD-L1

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.02

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@H](O)[C@H](C(O)=O)NCC1=CC(Cl)=C(OCC2=C(C)C(C3=CC=CC=C3)=CC=C2)C=C1OCC4=CC=C(S(=O)(F)=O)C=C4

Molecular Formula

C32H31ClFNO7S

Molecular Weight

628.11

References & Citations

[1]Cheng B, et al. Discovery of Small Molecule PD-L1 Inhibitors via Optimization of Solvent-Interaction Region for Cancer Immunotherapy. Chem Biol Drug Des. 2025 Jun;105 (6) :e70141.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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