Y040-7904

• Description:

  Y040-7904 is a mitophagy activator. Y040-7904 enhances mitophagy by promoting mitochondria transport to autophagosomes and the fusion of autophagosomes with autolysosomes. Y040-7904 induces mitophagy through the SIRT1/FoxO3 pathway. Y040-7904 upregulates the levels of Parkin, PINK1, and LC3II/I. Y040-7904 reduces amyloid-β (Aβ) accumulation in both in vitro and in vivo models of Alzheimer’s disease[1].

• Product Name Alternative:

  7- (β-D-Galactopyranosyloxy) -4-phenylchromen-2-one

• UNSPSC:

  12352005

• Target:

  Amyloid-β; Mitophagy; PINK1/Parkin

• Related Pathways:

  Autophagy; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Purity:

  99.3600

• Smiles:

  O=C1C=C(C2=CC=CC=C2)C3=CC=C(O[C@H]4[C@@H]([C@H]([C@@H](CO4)O)O)O)C=C3O1

• Molecular Formula:

  C20H18O7

• Molecular Weight:

  370.35

• References & Citations:

  [1]Wang Y, et al. An AI-assisted fluorescence microscopic system for screening mitophagy inducers by simultaneous analysis of mitophagic intermediates. Nat Commun. 2025 Jun 4;16 (1) :5179.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [889662-19-5]