KMT9-IN-1

CAT: 0804-HY-174450Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-174450Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

KMT9-IN-1 (Compound 8) is a KMT9 inhibitor and the ethyl ester prodrug of compound 7b. KMT9-IN-1 releases the active form 7b via esterases in cells. KMT9-IN-1 targets KMT9 in cells and reduces H4K12me1 levels. KMT9-IN-1 has antitumor activity against colon cancer. KMT9-IN-1 can be used in the research of prostate cancer and hepatocellular carcinoma[1].

CAS Number

2625406-61-1

UNSPSC

12352005

Target

Epigenetic Reader Domain

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O[C@@H]1[C@H](O)[C@@H](CN(CC[C@H](N)C(OCC)=O)CCCNCCC2=CC=C(OC3=CC=C(Cl)C=C3)C(F)=C2)C[C@H]1N4C=CC5=C(NC)N=CN=C54

Molecular Formula

C36H47ClFN7O5

Molecular Weight

712.25

References & Citations

[1]Wang S, et al. Structure-Guided Design of a KMT9 Inhibitor Prodrug with Cellular Activity. J Med Chem. 2025 Jul 10;68 (13) :13295-13320.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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T211462-01	KMT9-IN-1
T211207-01	KMT9-IN-2
OF59775-01	1,1,1,1,1-Kestoheptaose
N2864-5.1	1,1,1,1-Kestohexaose
112040	1,1,1,1-Kestohexose
410417-01	1,1,1-Trichloromethanesulfonic Acid 1,1'-Anhydride
IFA69273-01	1-Iodobicyclo[1.1.1]pentane
OR312388	1-Phenylbicyclo[1.1.1]pentane
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