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NEDD4-IN-1

CAT: 0804-HY-174375Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174375Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NEDD4-IN-1 (Compound 32) is a potent inhibitor of NEDD4 (IC50 = 0.12 μM) . NEDD4-IN-1 shows significant and comparable antiproliferative activity in H292 cell line. NEDD4-IN-1 demonstrates high plasma protein binding and medium-to-high in vitro clearance in both human and mouse models. NEDD4-IN-1 shows superior stability in mouse plasma. NEDD4-IN-1 has excellent potency, selectivity, and favourable in vitro ADME properties. NEDD4-IN-1 exhibits a systemic plasma clearance exceeding the hepatic blood flow in mouse model. NEDD4-IN-1 can be studied in anticancer research[1].
UNSPSC
12352005
Target
Others
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
N#C/C=C/CNCCCCN1C2=CC(Cl)=CC=C2CCC3=C1N(C)N=C3.O=C(O)/C=C\C(O)=O
Molecular Formula
C24H28ClN5O4
Molecular Weight
485.96
References & Citations
[1]Maspero, E., et al., (2025) . Structure-based design of potent and selective inhibitors of the HECT ligase NEDD4. Communications chemistry, 8 (1), 164.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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