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CYP51-IN-22

CAT: 0804-HY-174353Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174353Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CYP51-IN-22, the non-deuterated analog of CYP51-IN-23-d3 , is a potent and broad-spectrum CYP51 inhibitor.CYP51-IN-22 inhibits Aspergillus fumigatum with a MIC80 of 1 μg/mL. CYP51-IN-22 can prevent fungal phase transformation and biofilm formation. CYP51-IN-22 exhibits anti-drug resistance activity and fungal activity, and shows excellent safety for cells and significant pharmacological activity in mice. CYP51-IN-22 can be used for the study of invasive fungal infections (IFIs).
UNSPSC
12352005
Target
Cytochrome P450; Fungal
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
FC1=CC(F)=CC=C1C(CN(C)CC2=CC=C(N3CCN(C(C4=CC(Br)=CC=C4)=O)CC3)C=C2)(O)CN5C=NN=N5
Molecular Formula
C29H30BrF2N7O2
Molecular Weight
626.50
References & Citations
[1]Luo Z et al. Discovery of a potent, broad-spectrum and in vivo effective deuterated tetrazole CYP51 inhibitor. Eur J Med Chem. 2025 May 28;296:117817.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP51

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