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Skp2-IN-4

CAT: 0804-HY-174346-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-174346-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Skp2-IN-4 is an Skp2 inhibitor with a IC50 of 0.38 μM for Skp2-Cks1 binding. Skp2-IN-4 improves anti-tumor activity, inhibits the proliferation and induces S phase arrest by targeting Skp2. Skp2-IN-4 significantly enhances Cisplatin chemosensitivity by suppressing the tumor cell stemness in NCl-H1299 xenograft mice model, promising for lung cancer and esophageal cancer research[1].
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis; E1/E2/E3 Enzyme
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer
Purity
98.02
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN(CC1=CC=C(C#N)C=C1)C2=NC(C3=CC=CC=C3)=C(C4=CC=NC=C4)N=C2
Molecular Formula
C24H19N5
Molecular Weight
377.44
References & Citations
[1]Hu K, et al. Molecular hybridization strategy - discovery of 2,3-diarylpyrazine derivatives as potent Skp2 inhibitors with improved anti-tumor activity and enhanced cisplatin sensitivity. Eur J Med Chem. 2025 Oct 5; 295:117788.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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