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Anion transporter-4

CAT: 0804-HY-174148Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174148Size:1 Each
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Description
Anion transporter-4 (Compound 6) is a small-molecule anion transporter, which induces tubulin degradation and mitochondrial dysfunction. Anion transporter-4 can increase intracellular anion levels such as chloride ions by disrupting microtubule dynamics, promoting lipid peroxidation, and impairing mitochondrial function. Anion transporter-4 triggers ferroptosis to exert anticancer activity. Anion transporter-4 is promising for research of cancers[1].
UNSPSC
12352005
Target
Anion Exchangers; Ferroptosis
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel
Field of Research
Cancer
Smiles
FC1=CC(C2=NC3=C(C=C(C(F)(F)F)C=C3C(F)(F)F)N2)=CC(C4=NC5=C(C=C(C(F)(F)F)C=C5C(F)(F)F)N4)=C1
Molecular Formula
C24H9F13N4
Molecular Weight
600.33
References & Citations
[1]Hong XQ, et al. Ferroptosis of Cancer Cells via Tubulin Degradation and Mitochondrial Dysfunction: A Novel Mechanism of Anticancer Effect for Small-Molecule Anion Transporters. J Med Chem. 2025 Jun 12;68 (11) :10970-10990.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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