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TM471-1

CAT: 0804-HY-174129Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174129Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TM471-1 is an orally active and covalent Bruton's tyrosine kinase (BTK) inhibitor with IC50 values of 1.3 nM (BTKWT), >40,000 nM (BTKC481S), 7.9 nM (TEC) and 12.4 nM (TXK) . TM471-1 inhibits cell growth in vivo and in vitro, arrests cell cycle at G0/G1 phase and induces cell apoptosis[1].
CAS Number
2649008-95-5
UNSPSC
12352005
Target
Apoptosis; Btk
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(N)C1=C(C2=CC=C(OC3=CC=CC=C3)C=C2)N=C4N1NCC[C@H]4C5CCN(C(C=C)=O)CC5
Molecular Formula
C27H29N5O3
Molecular Weight
471.55
References & Citations
[1]Zhang D, et al. Discovery of Imidazo[1,2-b]pyridazine Derivatives as Potent and Highly Selective Irreversible Bruton's Tyrosine Kinase (BTK) Inhibitors. J Med Chem. 2025 Jun 12;68 (11) :10897-10929.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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