Products for Research Use Only
RegisterLogin

ID11916

CAT: 0804-HY-173640Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-173640Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ID11916 is an orally active androgen receptor (AR) antagonist and a phosphodiesterase 5 (PDE5) inhibitor. ID11916 blocks androgen binding to AR, nuclear translocation, and androgen-dependent transcriptional activity of AR, while increasing intracellular cGMP levels and activating PKG via inhibition. ID11916 shows potent anti-cancer effect in prostate cancer cell lines VCaP and 22Rv1 and in AR-positive breast cancer cell lines SK-BR-3[1].
CAS Number
2785317-21-5
UNSPSC
12352005
Target
Androgen Receptor; Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1C(C)(N(C(N1C2=CN=C(C(C(F)(F)F)=C2)C#N)=S)C3=CC=C(C(C4=NN5C(C(N4)=O)=C(N=C5CCC)C)=C3)OCC)C
Molecular Formula
C29H27F3N8O3S
Molecular Weight
624.64
References & Citations
[1]Jeong Eun Kim, et al. Abstract 5601: ID11916, a novel androgen receptor antagonist with cGMP-dependent protein kinase activation for next-generation therapeutics in AR positive tumors. Cancer Res (2025) 85 (8_Supplement_1) : 5601.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE5

Alternative Products

CatalogName
T206742-01ID11916

Popular Products