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ID11916

CAT: 0013-GTR19258337-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258337-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ID11916 is an orally active compound functioning as both an androgen receptor (AR) antagonist and a phosphodiesterase 5 (PDE5) inhibitor. It disrupts androgen binding to AR, impedes nuclear translocation, and blocks androgen-dependent transcriptional activity of AR, while simultaneously elevating intracellular cGMP levels by inhibiting PKG activation. Moreover, ID11916 exhibits potent anticancer effects in prostate cancer cell lines VCaP and 22Rv1, as well as in AR-positive breast cancer cell line SK-BR-3.
CAS Number
2785317-21-5
Field of Research
Metabolism Research
Smiles
N#CC1=NC=C (C=C1C (F) (F) F) N2C (=O) C (N (C=3C=CC (OCC) =C (C3) C4=NC (=O) C5=C (N=C (N5N4) CCC) C) C2=S) (C) C
Molecular Formula
C29H27F3N8O3S
Molecular Weight
624.637
Storage Conditions
-20°C
Notes
For research use only.

Alternative Products

CatalogName
T206742-01ID11916

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