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AMG410

CAT: 0804-HY-173632-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-173632-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMG410 is a non-covalent and selective pan-KRAS inhibitor with IC50 values of 1-4 nM for KRAS G12D, KRAS G12V, and KRAS G13D. AMG410 shows greater than 100-fold selectivity against both HRAS and NRAS. AMG410 is a dual GTP (on) - and GDP (off) -state inhibitor (Kd (GDP-state) of 1 nM; Kd (GTP-state) of 22 nM) . AMG410 blocks KRAS signaling in a cycling state-independent manner and also blocks proliferation in wildtype KRAS-amplified tumor cells. AMG410 can be used for the study of colorectal, pancreatic, and lung cancers[1][2].
CAS Number
3040175-17-2
UNSPSC
12352005
Target
Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.75
Solubility
DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC1=C(C2=C(C=NN3)C3=CC(Cl)=C2CCCO4)N=CC5=C1N=C(OC[C@]67C[C@@H](F)CN6CCC7)N=C5N8CCOC[C@@H](OC4=O)C8
Molecular Formula
C31H32ClF2N7O5
Molecular Weight
656.08
References & Citations
[1]Adriano BAUER, et al. Macrocyclic kras inhibitors and methods of use. WO2024107686A1.|[2]ND01 - AMG 410: An H/NRAS-sparing pan-KRAS inhibitor with dual GTP (on) /GDP (off) -state activity for the treatment of diverse KRAS-mutant tumors
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras

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