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DL5055

CAT: 0804-HY-173465Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173465Size:1 Each
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Description
DL5055 (compound 6k) is a potent and selective hCAR activator with an EC50 of 0.35 μM. DL5055 induces CYP2B6 expression and hCAR nuclear translocation in human primary hepatocytes[1].
CAS Number
2259710-89-7
UNSPSC
12352005
Target
Constitutive Androstane Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Smiles
O=C(NC1CC2=C(C=CC=C2)C1)C3=C(C4=CC=C5C=CC=CC5=C4)N=C6OC=CN36
Molecular Formula
C25H19N3O2
Molecular Weight
393.44
References & Citations
[1]Liang D, et al. Potent and Selective Human Constitutive Androstane Receptor Activator DL5055 Facilitates Cyclophosphamide-Based Chemotherapies. J Med Chem. 2025 Apr 10;68 (7) :7044-7061.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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