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DL5050

CAT: 0804-HY-134522Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-134522Size:1 Each
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Description
DL5050 is a selective and potent human constitutive androstane receptor (hCAR) agonist that does not activate pregnane X receptor (PXR) . DL5050 preferentially induces the expression of CYP2B6 (target of hCAR) over CYP3A4 (target of hPXR) on both the mRNA and protein levels. DL5050 can be used for the researches of cancer and metabolic disease, such as diabetes[1].
CAS Number
2259710-64-8
UNSPSC
12352005
Target
Constitutive Androstane Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Smiles
ClC1=CC=C(CO/N=C/C2=C(C3=CC=C4C=CC=CC4=C3)N=C5OC=CN52)C=C1Cl
Molecular Formula
C23H15Cl2N3O2
Molecular Weight
436.29
References & Citations
[1]Liang D, et al. DL5050, a Selective Agonist for the Human Constitutive Androstane Receptor. ACS Med Chem Lett. 2019 Jun 12;10 (7) :1039-1044.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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