G-6599

• Description :

  G-6599 is a SMARCA2/A4 target-anchored monovalent degrader with DC50 values of 0.018 nM and 0.056 nM, respectively. G-6599 has degradation activity and anti-proliferative effects in AR-dependent prostate cancer cell lines[1].

• UNSPSC :

  12352005

• Target :

  Epigenetic Reader Domain

• Related Pathways :

  Epigenetics

• Field of Research :

  Cancer

• Purity :

  92.10

• Smiles :

  OC1=CC=CC=C1C2=CC(N3CC4N(C5=CC(C#CCCN6CCCCCC6)=NC=C5)C(CC4)C3)=C(N)N=N2

• Molecular Formula :

  C31H37N7O

• Molecular Weight :

  523.67

• References & Citations :

  [1]Elisia Villemure, et al. Rational design of potent small molecule SMARCA2/A4 (BRM/BRG1) degraders acting via the recruitment of FBXO22. bioRxiv. 2025, 3, 7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2901806-51-5]