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LNS8801

CAT: 0804-HY-173178-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-173178-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LNS8801 is an orally active agonist of the G protein-coupled estrogen receptor (GPER) . By activating GPER, LNS8801 mediates downstream signaling pathways, such as promoting the production of cyclic adenosine monophosphate (cAMP) and activating the cAMP response element-binding protein (CREB) signaling, thereby exerting anti-tumor activities including inhibiting tumor cell proliferation, inducing cell differentiation, and enhancing tumor immunogenicity. LNS8801 can be used in the research of various cancers (e.g., melanoma, pancreatic cancer, colorectal cancer, lung cancer, etc.) and relevant studies exploring the roles of GPER in normal physiological and pathological processes[1].
CAS Number
925419-55-2
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
BrC(C([C@@]1([H])NC(C=CC(C(C)=O)=C2)=C2[C@]3([H])[C@@]1([H])CC=C3)=C4)=CC5=C4OCO5
Molecular Formula
C21H18BrNO3
Molecular Weight
412.28
References & Citations
[1]Natale CA, et al. LNS8801: An Enantiomerically Pure Agonist of the G Protein-Coupled Estrogen Receptor Suitable for Clinical Development. Cancer Res Commun. 2025 Apr 1;5 (4) :556-568.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3

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CatalogName
T206565-01LNS8801

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