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HNW005

CAT: 0804-HY-172778Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172778Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HNW005 is a dual inhibitor of NLRP3 inflammasome and urate transporter 1 (URAT1) . It has a KD value of 204.6 nM and an IC50 of 1.7 μM for inhibiting NLRP3 inflammasome activation, and an IC50 of 6.4 μM for inhibiting uric acid transmembrane transport. When administered at a dose of 2 mg/kg in vivo, HNW005 can achieve a uric acid reduction rate of 64.8%. It can exert anti - inflammatory, analgesic, and uric acid - lowering activities by inhibiting the activation of NLRP3 inflammasome and uric acid transmembrane transport. HNW005 can be used in the research of gouty arthritis[1].
UNSPSC
12352005
Target
NOD-like Receptor (NLR) ; URAT1
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
O=C(NC1=CC=CC=C1C(O)=O)C2=NNC(C3=CC=C(C(F)(F)F)C=C3)=C2
Molecular Formula
C18H12F3N3O3
Molecular Weight
375.30
References & Citations
[1]Sun M, et al. Scaffold hopping-based structural modification of tranilast led to the identification of HNW005 as a promising NLRP3 inflammasome and URAT1 dual inhibitor for the treatment of gouty arthritis. Eur J Med Chem. 2025 Apr 17;292:117644.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3

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CatalogName
T206955-01HNW005

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