HNW005

CAT: 0013-GTR19258142-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19258142-01Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

HNW005 is a dual inhibitor targeting the NLRP3 inflammasome and urate transporter 1 (URAT1) . It exhibits an inhibition constant (KD) of 204.6 nM and an IC50 of 1.7 μM for NLRP3 inflammasome activation, while demonstrating an IC50 of 6.4 μM for inhibiting uric acid transmembrane transport. At an administered dose of 2 mg/kg in vivo, HNW005 achieves a uric acid reduction rate of 64.8%, effectively providing anti-inflammatory, analgesic, and urate-lowering effects by inhibiting NLRP3 inflammasome activation and uric acid transport. HNW005 is applicable for research in gouty arthritis.

Field of Research

Immunology & Inflammation, Pharmacology & Drug Discovery

Storage Conditions

-20°C

Notes

For research use only.

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T206955-01	HNW005

HNW005

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