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LIB3S0280

CAT: 0804-HY-172620-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-172620-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LIB3S0280 is a potent TBK1 inhibitor with an IC50 value of 493.9 nM. LIB3S0280 exhibits better anticancer effects in pancreatic cancer cell lines with high TBK1 expression. LIB3S0280 inhibits TBK1 downstream signaling pathways, including PI3K/AKT and NF-κB. LIB3S0280 induces G2/M arrest, apoptosis and cellular senescence. LIB3S0280 can be used for pancreatic ductal adenocarcinoma (PDAC) research[1].
UNSPSC
12352005
Target
Akt; Apoptosis; Caspase; CDK; IKK; NF-κB; PARP; PI3K
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; NF-κB; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease; Inflammation/Immunology; Metabolic Disease
Purity
99.89
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=C(OC)C=C(CCNC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2Cl)C=C1
Molecular Formula
C22H25ClN4O5
Molecular Weight
460.91
References & Citations
[1]Wan-Hsi Shih, et al. Discovery of novel TANK-Binding Kinase 1 (TBK1) inhibitor against pancreatic ductal adenocarcinoma. Int J Biol Macromol. 2024 Dec;283 (Pt 1) :137296.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TBK1

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CatalogName
T206881-01LIB3S0280

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