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LIB3S0280

CAT: 0013-GTR19258215-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258215-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LIB3S0280 is a potent inhibitor of TBK1, with an IC50 of 493.9 nM. It suppresses TBK1 downstream signaling by reducing the phosphorylation of IκBα and AKT. LIB3S0280 causes G2/M phase arrest and induces apoptosis in pancreatic cancer cells. Notably, it exhibits significant inhibitory effects on pancreatic cancer cell lines with high TBK1 expression, with a 96-hour IC50 value ranging from 6.64-10.98 μM. LIB3S0280 shows potential for research in pancreatic ductal adenocarcinoma (PDAC) .
Field of Research
Cell Biology, Signal Transduction
Storage Conditions
-20°C
Notes
For research use only.

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CatalogName
T206881-01LIB3S0280

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