Neuroprotective agent 10

• Description:

  Neuroprotective agent 10 (Compound 11c) is a brain-penetrant neuroprotective agent. Neuroprotective agent 10 scavenges ABTS radicals (scavenging IC50: 9.20 μM), DPPH radicals (scavenging IC50: 7.09 μM) and superoxide anion radicals (inhibition percentage: 48.4%) . Neuroprotective agent 10 also alleviates H2O2-induced oxidative damage and LPS-induced neuroinflammation with antiepileptic activity. Neuroprotective agent 10 is promising for research of epilepsy and neuroprotection[1].

• UNSPSC:

  12352005

• Target:

  Others

• Related Pathways:

  Others

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Smiles:

  OC1=C(OC)C=C(CNCCCN2CCCC(C(N)=O)C2)C=C1

• Molecular Formula:

  C17H27N3O3

• Molecular Weight:

  321.41

• References & Citations:

  [1]Li W, et al. Design, synthesis and biological evaluation of N-substituted nipecotamide derivatives as multifunctional agents for epilepsy treatment. Eur J Med Chem. 2025 Apr 10;292:117613.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported