3′,5′-DiOA-dC

CAT: 0804-HY-172533Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-172533Size:1 Each
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Description
3’,5’-DiOA-dC is a hydrophobic nucleotide lipid and a ligand for the STING agonist c-di-GMP (CDG) . 3’,5’-DiOA-dC can assemble with CDG and form stable cyclic dinucleotide nanoparticles via various supramolecular forces driven by molecular recognition. 3’,5’-DiOA-dC can decrease tumor weight and volume, increase CD8 T cell, neutrophils as well as NK cell counts in tumor microenvironment in combination with CDG. 3’,5’-DiOA-dC also increases the levels of TNF-α and IFN-γ in murine melanoma model[1].
UNSPSC
12352005
Target
STING
Related Pathways
Immunology/Inflammation
Field of Research
Cancer
Smiles
NC1=NC(N(C=C1)C2OC(C(C2)OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O
Molecular Formula
C45H77N3O6
Molecular Weight
756.11
References & Citations
[1]Xu, L., et al., Supramolecular cyclic dinucleotide nanoparticles for STING-mediated cancer immunotherapy. ACS Nano 17 (11), 10090-10103, 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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