3′,5′-DiOA-dC

• Description :

  3’,5’-DiOA-dC is a hydrophobic nucleotide lipid and a ligand for the STING agonist c-di-GMP (CDG) . 3’,5’-DiOA-dC can assemble with CDG and form stable cyclic dinucleotide nanoparticles via various supramolecular forces driven by molecular recognition. 3’,5’-DiOA-dC can decrease tumor weight and volume, increase CD8 T cell, neutrophils as well as NK cell counts in tumor microenvironment in combination with CDG. 3’,5’-DiOA-dC also increases the levels of TNF-α and IFN-γ in murine melanoma model[1].

• UNSPSC :

  12352005

• Target :

  STING

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Cancer

• Smiles :

  NC1=NC(N(C=C1)C2OC(C(C2)OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O

• Molecular Formula :

  C45H77N3O6

• Molecular Weight :

  756.11

• References & Citations :

  [1]Xu, L., et al., Supramolecular cyclic dinucleotide nanoparticles for STING-mediated cancer immunotherapy. ACS Nano 17 (11), 10090-10103, 2023.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported