3′,5′-DiOA-dC

• Description:

  3’,5’-DiOA-dC is a hydrophobic nucleotide lipid and a ligand for the STING agonist c-di-GMP (CDG) . 3’,5’-DiOA-dC can assemble with CDG and form stable cyclic dinucleotide nanoparticles via various supramolecular forces driven by molecular recognition. 3’,5’-DiOA-dC can decrease tumor weight and volume, increase CD8 T cell, neutrophils as well as NK cell counts in tumor microenvironment in combination with CDG. 3’,5’-DiOA-dC also increases the levels of TNF-α and IFN-γ in murine melanoma model[1].

• UNSPSC:

  12352005

• Target:

  STING

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Cancer

• Smiles:

  NC1=NC(N(C=C1)C2OC(C(C2)OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O

• Molecular Formula:

  C45H77N3O6

• Molecular Weight:

  756.11

• References & Citations:

  [1]Xu, L., et al., Supramolecular cyclic dinucleotide nanoparticles for STING-mediated cancer immunotherapy. ACS Nano 17 (11), 10090-10103, 2023.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported