NUCC-0200808

• Description:

  NUCC-0200808 (Compound 12g) is an inhibitor of MNK1 with an IC50 of 42 nM. NUCC-0200808 reduces eIF4E phosphorylation and cell viability in AML cells, and induces apoptosis. NUCC-0200808 holds promise for research in the field of leukemia[1].

• UNSPSC:

  12352005

• Target:

  MNK

• Related Pathways:

  MAPK/ERK Pathway

• Field of Research:

  Cancer

• Smiles:

  ClC1=CN=C(N2C=NC3=C2C=CC=C3)N=C1OC4CCNC4

• Molecular Formula:

  C15H14ClN5O

• Molecular Weight:

  315.76

• References & Citations:

  [1]Vagadia PP, et al. Discovery of Potent and Selective MNK Kinase Inhibitors for the Treatment of Leukemia. J Med Chem. 2025 Mar 13;68 (5) :5824-5844.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MNK1; MNK2